解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:UNLABELLED:Ebola viruses (EBOV) cause severe disease in humans and nonhuman primates with high mortality rates and continue to emerge in new geographic locations, including several countries in West Africa, the site of a large ongoing outbreak. Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense mole...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02344-14
更新日期:2015-02-10 00:00:00
abstract:UNLABELLED:Diverse colony morphologies are a hallmark of Burkholderia pseudomallei recovered from infected patients. We observed that stresses that inhibit aerobic respiration shifted populations of B. pseudomallei from the canonical white colony morphotype toward two distinct, reversible, yet relatively stable yellow ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02462-14
更新日期:2015-02-03 00:00:00
abstract:UNLABELLED:Fast, definitive diagnosis of Creutzfeldt-Jakob disease (CJD) is important in assessing patient care options and transmission risks. Real-time quaking-induced conversion (RT-QuIC) assays of cerebrospinal fluid (CSF) and nasal-brushing specimens are valuable in distinguishing CJD from non-CJD conditions but h...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02451-14
更新日期:2015-01-20 00:00:00
abstract:UNLABELLED:Here we present an extensive genomic and genetic analysis of Escherichia coli strains of serotype O78 that represent the major cause of avian colisepticemia, an invasive infection caused by avian pathogenic Escherichia coli (APEC) strains. It is associated with high mortality and morbidity, resulting in sign...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01681-14
更新日期:2015-01-13 00:00:00
abstract:UNLABELLED:Osteomyelitis is a difficult-to-eradicate bone infection typically caused by Staphylococcus aureus. In this study, we investigated the in vivo transcriptional adaptation of S. aureus during bone infection. To this end, we determined the transcriptome of S. aureus during the acute (day 7) and chronic (day 28)...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01775-14
更新日期:2014-12-23 00:00:00
abstract:UNLABELLED:Rapidly fatal cases of invasive fungal infections due to a fungus later identified as Saprochaete clavata were reported in France in May 2012. The objectives of this study were to determine the clonal relatedness of the isolates and to investigate possible sources of contamination. A nationwide alert was lau...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02309-14
更新日期:2014-12-16 00:00:00
abstract:UNLABELLED:Candida albicans is a major life-threatening human fungal pathogen in the immunocompromised host. Host defense against systemic Candida infection relies heavily on the capacity of professional phagocytes of the innate immune system to ingest and destroy fungal cells. A number of pathogens, including C. albic...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01874-14
更新日期:2014-12-02 00:00:00
abstract:UNLABELLED:The ability to cultivate food is an innovation that has produced some of the most successful ecological strategies on the planet. Although most well recognized in humans, where agriculture represents a defining feature of civilization, species of ants, beetles, and termites have also independently evolved sy...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02077-14
更新日期:2014-11-18 00:00:00
abstract:UNLABELLED:Pasteurella multocida toxin (PMT) induces atrophic rhinitis in animals, which is characterized by a degradation of nasal turbinate bones, indicating an effect of the toxin on bone cells such as osteoblasts and osteoclasts. The underlying molecular mechanism of PMT was defined as a persistent activation of he...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.02190-14
更新日期:2014-11-11 00:00:00
abstract:UNLABELLED:In the context of deciphering the metabolic strategies of the obligate pathogenic fungi in the genus Pneumocystis, the genomes of three species (P. carinii, P. murina, and P. jirovecii) were compared among themselves and with the free-living, phylogenetically related fission yeast (Schizosaccharomyces pombe)...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01834-14
更新日期:2014-11-04 00:00:00
abstract::Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease. During enterotoxemia, the nearly inactive ETX prototoxin is produced in the intestines but then must be activated by proteolytic ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01994-14
更新日期:2014-10-21 00:00:00
abstract::Chlamydia trachomatis is an obligate intracellular human pathogen that grows inside a membranous, cytosolic vacuole termed an inclusion. Septins are a group of 13 GTP-binding proteins that assemble into oligomeric complexes and that can form higher-order filaments. We report here that the septins SEPT2, -9, -11, and p...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01802-14
更新日期:2014-10-07 00:00:00
abstract:UNLABELLED:Small colony variants (SCVs) are naturally occurring subpopulations of bacteria. The clinical characteristics and treatment outcomes of patients with prosthetic joint infection (PJI) caused by staphylococcal SCVs are unknown. This study was a retrospective series of 113 patients with staphylococcal PJI, with...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01910-14
更新日期:2014-09-30 00:00:00
abstract:UNLABELLED:Kaposi's sarcoma (KS), caused by KS-associated herpesvirus (KSHV), is the most common cancer among HIV-infected patients in Malawi and in the United States today. In Malawi, KSHV is endemic. We conducted a cross-sectional study of patients with HIV infection and KS with no history of chemo- or antiretroviral...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01633-14
更新日期:2014-09-23 00:00:00
abstract:UNLABELLED:The route taken by papillomaviruses from the cell surface to the nucleus during infection is incompletely understood. Here, we developed a novel human papillomavirus 16 (HPV16) pseudovirus in which the carboxy terminus of the minor capsid protein L2 is exposed on the exterior of the intact capsid prior to ce...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01777-14
更新日期:2014-09-16 00:00:00
abstract:UNLABELLED:Large-scale rearrangements may be important in evolution because they can alter chromosome organization and gene expression in ways not possible through point mutations. In a long-term evolution experiment, twelve Escherichia coli populations have been propagated in a glucose-limited environment for over 25 ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01377-14
更新日期:2014-09-09 00:00:00
abstract:UNLABELLED:The C-type lectin receptor Dectin-1 is expressed mainly on myeloid cells mediating the immune response targeting respiratory pathogens such as Aspergillus fumigatus and Mycobacterium tuberculosis. The pulmonary epithelium serves as an important interface for interactions between these pathogens and the respi...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01492-14
更新日期:2014-08-26 00:00:00
abstract::Inhibition of apoptotic death of macrophages by Mycobacterium tuberculosis represents an important mechanism of virulence that results in pathogen survival both in vitro and in vivo. To identify M. tuberculosis virulence determinants involved in the modulation of apoptosis, we previously screened a transposon bank of ...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01278-14
更新日期:2014-08-19 00:00:00
abstract:UNLABELLED:The aerial surfaces of plants, or phyllosphere, are microbial habitats important to plant and human health. In order to accurately investigate microbial interactions in the phyllosphere under laboratory conditions, the composition of the phyllosphere microbiota should be representative of the diversity of mi...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01564-14
更新日期:2014-08-12 00:00:00
abstract::Uncultured and therefore uncharacterized Bacteroidetes lineages are ubiquitous in many natural ecosystems which specialize in lignocellulose degradation. However, their metabolic contribution remains mysterious, as well-studied cultured Bacteroidetes have been shown to degrade only soluble polysaccharides within the h...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01401-14
更新日期:2014-08-05 00:00:00
abstract::The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01183-14
更新日期:2014-07-29 00:00:00
abstract::Food-borne pathogens are ongoing problems, and new pathogens are emerging. The impact of fungi, however, is largely underestimated. Recently, commercial yogurts contaminated with Mucor circinelloides were sold, and >200 consumers became ill with nausea, vomiting, and diarrhea. Mucoralean fungi cause the fatal fungal i...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01390-14
更新日期:2014-07-08 00:00:00
abstract::Viral 2',5'-phosphodiesterases (2',5'-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2',5'-oligoadenylate (2-5A) activators of RNase L. A kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) to localize and organize cyclic AMP (cAMP) s...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01312-14
更新日期:2014-07-01 00:00:00
abstract::The resurgence of pertussis (whooping cough) in countries with high vaccination coverage is alarming and invites reconsideration of the use of current acellular pertussis (aP) vaccines, which have largely replaced the old, reactogenic, whole-cell pertussis (wP) vaccine. Some drawbacks of these vaccines in terms of lim...
journal_title:mBio
pub_type: 社论
doi:10.1128/mBio.01339-14
更新日期:2014-06-10 00:00:00
abstract:UNLABELLED:The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV(+) newborns. We previously reported improved preclinical efficacy and safety of the recombinant vaccine candi...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01262-14
更新日期:2014-06-03 00:00:00
abstract:UNLABELLED:Protein-protein interactions are important for virtually every biological process, and a number of elegant approaches have been designed to detect and evaluate such interactions. However, few of these methods allow the detection of dynamic and real-time protein-protein interactions in bacteria. Here we descr...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01050-14
更新日期:2014-05-20 00:00:00
abstract:UNLABELLED:Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized by MRSA and can become infected. We sequenced the genomes of 46 multilocus sequence type...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00985-13
更新日期:2014-05-13 00:00:00
abstract::ABSTRACT The type VII secretion systems are conserved across mycobacterial species and in many Gram-positive bacteria. While the well-characterized Esx-1 pathway is required for the virulence of pathogenic mycobacteria and conjugation in the model organism Mycobacterium smegmatis, Esx-3 contributes to mycobactin-media...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.01073-14
更新日期:2014-05-06 00:00:00
abstract::ABSTRACT The major clonal lineages of the human pathogen Staphylococcus aureus produce cell wall-anchored anionic poly-ribitol-phosphate (RboP) wall teichoic acids (WTA) substituted with d-Alanine and N-acetyl-d-glucosamine. The phylogenetically isolated S. aureus ST395 lineage has recently been found to produce a uni...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00869-14
更新日期:2014-04-08 00:00:00
abstract::The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where t...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00884-14
更新日期:2014-02-25 00:00:00
abstract:UNLABELLED:Heteroresistance refers to phenotypic heterogeneity of microbial clonal populations under antibiotic stress, and it has been thought to be an allocation of a subset of "resistant" cells for surviving in higher concentrations of antibiotic. The assumption fits the so-called bet-hedging strategy, where a bacte...
journal_title:mBio
pub_type: 杂志文章,多中心研究
doi:10.1128/mBio.00942-13
更新日期:2014-02-11 00:00:00
abstract:UNLABELLED:Nap1 has long been identified as a potential septin regulator in yeasts. However, its function and regulation remain poorly defined. Here, we report functional characterization of Nap1 in the human-pathogenic fungus Candida albicans. We find that deletion of NAP1 causes constitutive filamentous growth and ch...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00915-13
更新日期:2014-02-04 00:00:00
abstract:UNLABELLED:Exploiting mechanisms of utilizing the sugar d-galactose in Escherichia coli as a model system, we explored the consequences of accumulation of critical intermediates of the d-galactose metabolic pathways by monitoring cell growth, metabolites, and transcript profiles. These studies revealed both metabolic n...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00972-13
更新日期:2014-01-28 00:00:00
abstract:UNLABELLED:The nucleus has emerged as a key target for nucleomodulins, a family of effectors produced by bacterial pathogens to control host transcription or other nuclear processes. The virulence factor LntA from Listeria monocytogenes stimulates interferon responses during infection by inhibiting BAHD1, a nuclear pro...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00775-13
更新日期:2014-01-21 00:00:00
abstract::Measurements of the presence of prions in biological tissues or fluids rely more and more on cell-free assays. Although protein misfolding cyclic amplification (PMCA) has emerged as a valuable, sensitive tool, it is currently hampered by its lack of robustness and rapidity for high-throughput purposes. Here, we made a...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00829-13
更新日期:2013-12-31 00:00:00
abstract:UNLABELLED:The group of proteins known as serine protease autotransporters of Enterobacteriaceae (SPATE) is a growing family of serine proteases secreted to the external milieu by the type V secretion system. Pet toxin and some other SPATE belong to the class 1 cytotoxic SPATE, which have comparable protease strength o...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00838-13
更新日期:2013-12-10 00:00:00
abstract:UNLABELLED:Small RNAs play a critical role in host-pathogen interaction. Indeed, small RNA-mediated silencing or RNA interference (RNAi) is one of the earliest forms of antiviral immunity. Although it represents the main defense system against viruses in many organisms, the antiviral role of RNAi has not been clearly p...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00698-13
更新日期:2013-11-19 00:00:00
abstract::While Shiga toxins (Stx) are key determinants of enterohemorrhagic Escherichia coli (EHEC) pathophysiology in humans, their dissemination to target organs following gastrointestinal EHEC infection is still poorly understood. Most types of Stx target cells with globotriaosylceramide (Gb3) receptors, which are expressed...
journal_title:mBio
pub_type: 评论,杂志文章
doi:10.1128/mBio.00868-13
更新日期:2013-11-12 00:00:00
abstract:UNLABELLED:Many viruses induce acute T cell-independent (TI) B cell responses due to their repetitive epitopes and the induction of innate cytokines. Nevertheless, T cell help is thought necessary for the development of long-lasting antiviral antibody responses in the form of long-lived plasma cells and memory B cells....
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00812-13
更新日期:2013-11-05 00:00:00
abstract:UNLABELLED:Enoyl-acyl carrier protein (enoyl-ACP) reductase catalyzes the last step of the elongation cycle in the synthesis of bacterial fatty acids. The Enterococcus faecalis genome contains two genes annotated as enoyl-ACP reductases, a FabI-type enoyl-ACP reductase and a FabK-type enoyl-ACP reductase. We report tha...
journal_title:mBio
pub_type: 杂志文章
doi:10.1128/mBio.00613-13
更新日期:2013-10-01 00:00:00